MuSiCa (Mutational Signatures in Cancer) is a shiny-based web application aimed to visualize the somatic mutational profile of a series of provided samples (different formats are allowed) and to extract the contribution of the reported mutational signatures (Alexandrov L.B. et al., Nature (2013), Catalogue Of Somatic Mutations In Cancer, COSMIC (2017)) on their variation profile. It is mainly based on the MutationalPatterns R package (Blokzijl et al., Genome Medicine (2018)).
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It appears that package sourcetools was added as a dependency for shiny 0.14. Usually, update.packages should take care of installing these added dependencies automatically. This worked on my installation, but you may try to install.packages(c('sourcetools', 'shiny')) manually. Does this work? If not, are you using Windows, MacOS or Linux?
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Please give credit and cite MuSiCa app when you use it for your genomic analysis (Díaz-Gay et al., BMC Bioinformatics (2018)).
Running the app
There are many ways to download and run Mutational Signatures ShinyApp:
First check the dependencies (you only need to do this once):
Then load the shiny app:
Other ways to load the app:
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January 2023
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